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pentobarbital will lessen the level or outcome of buprenorphine, lengthy-performing injection by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Clients who transfer to buprenorphine prolonged-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers need to be monitored to be sure b